Dr. Ahmed Al-Marzouqi       
       
Associate Professor
Department of Biochemistry
Phone: 971 3 7137 478
Fax: 971 3 7672033
Email: ahmedh@uaeu.ac.ae


College of Medicine and Health Sciences

United Arab Emirates University
P.O.Box 17666, Al-Ain
United Arab Emirates
Research Interest
Understanding the mechanisms of action of the protein complexes that regulate gene expression by modifying the structure of chromatin  
Transcription Regulation in Eukaryotes 
Selected Publications
Attoub S., Hassan A. H., Vanhoecke B., Iratni R., Takahashi T., Gaben A. M., Bracke M., Awad S., John A., Kamalboor H. A., Al Sultan M. A., Arafat K., Gespach C., Petroianu G. (2011). Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells. Eur J Pharmacol. 651(1-3):18-25.  
Al-Neyadi S. S., Hassan A. H., Abdou I. M. (2011). Microwave-Assisted Synthesis of 2(1H)-Pyridones and Their Glucosides as Cell Proliferation Inhibitors. Nucleosides Nucleotides Nucleic Acids. 30(2):120-34. 
Sharma C., Sadrieh L., Priyani A., Ahmed M, Hassan A. H., Hussain A. (2010). Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells. Cancer Epidemiol. 2010 Oct 16. [Epub ahead of print]. 
Awad S., Ryan D., Prochasson P., Owen-Hughes T. and Hassan A. H. (2010). The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol. Chem. 26;285(13):9477-84. 
Katerina E. Paleologou, Christine L. Kragh, David M. A. Mann, Sultan A. Salem, Rania Al-Shami, David Allsop, Ahmed H. Hassan, Poul H. Jensen, Omar M. A. El-Agnaf. (2009). Detection of elevated levels of soluble α-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies. Brain. 132 (Pt 4):1093-101. 
Salma Awad and Ahmed H. Hassan. (2008). The Swi2/Snf2 Bromodomain Is Important for the Full Binding and Remodeling Activity of the SWI/SNF Complex on H3- and H4-acetylated Nucleosomes. Ann N Y Acad Sci. 1138:366-75. 
Hassan A.H., Awad S., Al-Natour Z., Othman S., Mustafa .F, and Rizvi T.A. (2007). Selective recognition of acetylated histones by bromodomains in transcriptional co-activators. Biochem J. 402(1), 125-133. 
Al-Natour Z., and Hassan A.H. (2007). Effect of salt on the binding of the linker histone H1 to DNA and nucleosomes. DNA Cell Biol. 26(6), 445-452. 
Eberharter, A., Sterner, D.E., Schieltz, D., Hassan, A.H., Yates, J.R. 3rd, Berger, S.L., and J.L. Workman (1999). The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae. Mol. Cell. Biol. 19 (10): 6621-31. 
Hassan A.H., Awad S., and Prochasson P. (2006). The Swi2/Snf2 bromodomain is required for the displacement of SAGA and the octamer transfer of SAGA-acetylated nucleosomes. J Biol. Chem. 281(26):18126-34. 
Prochasson, P., Neely, K.E., Hassan, A.H., Li, B. and Workman, J.L. (2003). Targeting activity is required for SWI/SNF function in vivo and is accomplished through two partially redundant activator interaction domains. Molecular Cell (12): 983-990. 
Hassan, A.H., Neely, K.E., Vignali, M., Reese, J.C., and Workman, J.L. (2001). Promoter targeting of chromatin-modifying complexes. Front. Biosci., 2001 Sep 1;6:D1054-64. 
Hassan, A.H., Neely, K.E., and Workman, J.L. (2001). Histone Acetyltransferases stabilize SWI/SNF at promoter nucleosomes. Cell 104(6): 817-827. 
Vignali, M., Hassan, A.H., Neely, K.E., Workman, J.L. (2000). ATP-dependent chromatin remodeling complexes. Mol. Cell. Biol. 20 (6): 1899-1910. 
Wallberg, A.E., Neely, K.E., Hassan, A.H., Gustafsson, J.A., Workman, J.L. and Wright, A.P.H. (2000). Recruitment of the SWI-SNF chromatin remodeling complex as a mechanism of gene activation by the glucocorticoid receptor t1 activation domain. Mol. Cell. Biol. 20 (6): 2004-2013. 
Hassan, A.H., Prochasson, P., Neely, K.E., Galasinki, S.C., Chandy, M., Carrozza, M.J. and Workman, J.L. (2002). Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes. Cell 111(3): 369-79. 
Neely, K.E., Hassan, A.H., Wallberg, A.E., Steger, D.J., Cairns, B.R., Wright, A.P.H., Workman, J.L. (1999). Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays. Mol. Cell 4 (4): 649-55. 
Neely, K.E., Hassan, A.H., Brown, C.E., Howe, L., and Workman, J.L. (2002). Transcription activator interactions with multiple SWI/SNF subunits. Mol Cell Biol. 22(6):1615-25. 
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